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The US is not slated for inclusion.

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Hydroxychloroquine, the form of the drug that will now be used 'compassionately' in the US, was given to 24 out of 36 trial participants. Half of them cleared the infection entirely, according to an early announcement of the results on Wednesday. Patients treated with hydroxychloroquine improved more quickly and broke their fevers earlier than those who did not receive the drug. The drug is also included in China's treatment guidelines for COVID - described there as 'chloroquine phosphate - for use in patients between 18 and It is one of five antivirals suggested in the 7th edition of China's treatment plan , which also cautions the drug should not be given to patients with heart disease, as it has potential cardiac side effects.

But overall, the drug seems to be a powerful one against viruses in general, and for COVID in particular. Developed during World War II and approved by the the Food and Drug Administration FDA in , hydroxychloroquine cured about half of the 24 patients who received the drug there were 36 included in a French clinical trial published yesterday.

It was the first clinical trial of the drug for treating COVID after Chinese scientists found that it killed the virus in lab experiments, according to a study published in the Clinical Infectious Diseases Journal on March 9. US patients with 'mild' coronavirus disease are currently being recruited for a trial of hydroxychloroquine sold under the brand name Plaquenil , to be tested against the effects of another pair of antivirals, posted to clincaltrials. The number of coronavirus cases in the US has dramatically increased in the last two weeks.

As of Friday, cases among Americans had surpassed 18, In the span of less than half an hour, Americans were told by Trump that the drug was approved, then by Hahn that it is not. Although having a runny nose doesn't rule out coronavirus, it doesn't thus far appear to be a primary symptom. Most people only become mildly ill, but the infection can turn serious and even deadly, especially for those who are older or have underlying health conditions.

Avoid people with these symptoms. If you develop them, call your health care provider before going to the hospital or doctor, so they and you can prepare to minimize possible exposure if they suspect you have coronavirus. Hydroxychloroquine is also used to treat some forms of arthritis in some instances. When it was released half-a-century ago, the malaria drug was hailed for having milder side effects than its predecessor. If it's used long-term, the treatment can irreversibly damage the retina, as signalled by trouble focusing, streaks of flashes of light in patients' vision and eye swelling or color changes.

The drug can cause strange, bad and vivid dreams and difficulty sleeping. Taking hydroxychloronoquine can also cause your heart to race, trigger headache, fainting, severe dizziness, nausea, a slow heart rate or weak pulse, muscle weakness, numbness and tingly, anxiety and irritability and low blood counts. Still, with the death toll of coronavirus nearing in the US, even a drug with significant side effects would be cause for hope in the battle against coronavirus, for which there are currently no proven treatments.

Because it is already on the market and FDA approved for other uses, hydroxychloroquine can be more easily used off-label, so long as patients qualify to receive it under the Compassionate Use Act. That may mean prescriptions of the drug will only be approved for use in the most severely ill patients, although Hahn did not specify the criteria for prescribing hydroxoychloroquine to coronavirus patients.

It could be months before the drug is widely distributed, if the data the slowly trickles in on the select patients approved to be treated with it under Compassionate Use and clinical trials suggest that it is safe and effective. Until a proven treatment or vaccine for coronavirus is available - which could be months, at leat for the former, and more than a year for the latter - social distancing and supportive care via short-supplied ventilators remain the best hope for stemming the coronavirus pandemic in the US.

Keep them at home. Do not send them to school. Contact your medical provider. Keep the entire household at home. Do not go to work. Do not go to school. You and your employers should follow CDC guidance to protect your health at work. The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline. By posting your comment you agree to our house rules.

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Share this article Share. Already in France, the drug has been tested in 36 patients. Avoid touching your face. Sneeze or cough into a tissue, or the inside of your elbow. Disinfect frequently used items and surfaces as much as possible. Jars of the drug not intended for human consumptio Share or comment on this article: Prices surge for fish tank product with chemical tested as COVID drug e-mail Hydroxychloroquine and azithromycin are associated with QT prolongation and caution is advised when considering these drugs in patients with chronic medical conditions e. Hydroxychloroquine is currently under investigation in clinical trials for pre-exposure or post-exposure prophylaxis of SARS-CoV-2 infection, and treatment of patients with mild, moderate, and severe COVID In the United States, several clinical trials of hydroxychloroquine for prophylaxis or treatment of SARS-CoV-2 infection are planned or will be enrolling soon.

Lopinavir-ritonavir did not show promise for treatment of hospitalized COVID patients with pneumonia in a recent clinical trial in China [ 8 ].

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This trial was underpowered, and lopinavir-ritonavir is under investigation in a World Health Organization study. Several other drugs are under investigation in clinical trials or are being considered for clinical trials of prophylaxis or treatment of COVID in the United States and worldwide. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Section Navigation. Minus Related Pages. Remdesivir Remdesivir is an investigational intravenous drug with broad antiviral activity that inhibits viral replication through premature termination of RNA transcription and has in-vitro activity against SARS-CoV-2 and in-vitro and in-vivo activity against related betacoronaviruses [ ].

The manufacturer is currently transitioning the provision of emergency access to remdesivir from individual compassionate use requests to an expanded access program. The expanded access program for the United States is under rapid development. Other Drugs Lopinavir-ritonavir did not show promise for treatment of hospitalized COVID patients with pneumonia in a recent clinical trial in China [ 8 ]. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus nCoV in vitro.

Cell Res. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. Broad-spectrum antiviral GS inhibits both epidemic and zoonotic coronaviruses.

Sci Transl Med. Int J Antimicrob Agents. Clin Infect Dis. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID associated pneumonia in clinical studies.