Zinc should be looked at more. Zinc is known to inhibit the viral RNA polymerase and the chloroquine acts as a zinc ionophore to rapidly transport zinc ions through cell membranes into the cytoplasm where they are needed. For most normal healthy people, there is no need for ionophores, our natural zinc transporter proteins are good enough for the job. Keeping zinc levels well maintained by zinc supplementation will indeed help prevent the rapid multiplying of viruses.
Many people have seen the effects of zinc lozenges to beat the common cold. Thank god for glowing testimonials for sketchy cures made by people named after the purported cures. Thank god for glowing trolling done by people named after a math variable… What a contribution! It is perfectly reasonable to propose that zinc and chloroquine could have synergistic effects. Synergy does not require individual efficacy.
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Considering the properties and MoA at work it is something at least worth looking into. At least one animal study has found zero effect of dietary zinc on CoV etiology. Different one, though. Jones is already pushing zinc aggressively, probably because he has pallets of a slow moving supplement that contains a bit of zinc gathering dust in his warehouse.
Azi is a pretty obvious choice to co-dose. Chalk up another spectacularly bad call for Vallance, Witty and Slaoui. JP would have known better.
Clinical evidence also does not support the use of steroids for Covid Lancet 7 Feb Steroids have many many effects, but a primary one is anti-inflammatory. Hence, as others as noted, we need to be careful about recommending treatments without good data, particularly when available data suggests the treatment could make patients worse. So at best this small non-random open label study means nothing more than more research is needed …. There is a paper doing the rounds about a soluble derivative of aspirin with in vitro activity against SARS2 and potential for inhalation administration when they say potential, note the IV dose would be lethal….
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It is a Furin protease, and has been used to successfully treat feline infectious peritonitis, which is caused by the coronavirus FeCoV. Is carrimycin a man made macrolide? Obviously the combination of QT prolonging drugs sounds dangerous. The french study, right or wrong, suggests that azithromycin might be the bigger addition. Would love to see study on azithromycin alone, as this drug is generally well tolerated and would not produce the combination QT side effect.
Scary to see mass use of azithromycin without significant proof, especially with this drugs tendency to promote resistance. HCQ has a 22 day half life in the average human, so the french study would be gradually building up a dose, which eventually is therapeutic. A lot of this puzzle has to be in the loading dose that is eventually needed if the effect is happening. Anyone know if people on high dose long-term HCQ in the RA or Lupus community are mysteriously not getting sick despite being immunocompromised?
Azithromycin Zithromax is also an anti-inflammatory, used for treating lung problems. Your email address will not be published. Time limit is exhausted. All rights Reserved. A Nonny Mouse says:. Barry says:. Who Dr. Polynices says:. Former Merckoid says:. Sharon wong says:. Dennis K Yavorsky says:. Texas Carbonyl says:. TScond says:. Suzanne Roy1 says:. Silence Hand says:.
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TallDave says:. Sunyilo says:. WFH says:. Calvin says:. Standard Deviant says:. Stephen Fitzsimmons says:. Lars says:. Old Timer says:. Mark says:. AR says:. Bill Sellers says:. MTK says:. Bruce says:. An Old Chemist says:. Pajas says:. In vitro studies have shown that dasatinib has the potential to prolong the QT interval.
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Degarelix: Major Avoid coadministration of hydroxychloroquine and degarelix. QTc prolongation has been reported with the use of degarelix. Desflurane: Major Avoid coadministration of hydroxychloroquine and halogenated anesthestics.
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Halogenated anesthetics can prolong the QT interval. Desipramine: Major Avoid coadministration of hydroxychloroquine and tricyclic antidepressants. Deutetrabenazine: Major Hydroxychloroquine prolongs the QT interval and should not be administered with other drugs known to prolong the QT interval. Clinically relevant QTc prolongation may occur with deutetrabenazine. Dextromethorphan; Promethazine: Major Avoid coadministration of hydroxychloroquine and promethazine.
Dextromethorphan; Quinidine: Major Avoid coadministration of hydroxychloroquine and quinidine. Quinidine administration is associated with QT prolongation and TdP. Diazepam: Moderate Caution is warranted with the coadministration of hydroxychloroquine and antiepileptic drugs, such as diazepam. Digoxin: Moderate Digoxin serum concentrations have been reported to increase when hydroxychloroquine was added. Hydroxychloroquine may inhibit P-glycoprotein P-gp.
Digoxin is a substrate for P-gp transport. For patients on a stable digoxin regimen and initiating hydroxychloroquine, no initial dose adjustment of either drug has been advised; however, serum digoxin concentrations should be monitored and used for digoxin dose titration as clinically necessary. Dihydrocodeine; Guaifenesin; Pseudoephedrine: Moderate Concomitant use of dihydrocodeine with hydroxychloroquine may increase dihydrocodeine plasma concentrations, but decrease the plasma concentration of the active metabolite, dihydromorphine, resulting in reduced efficacy or symptoms of opioid withdrawal.
Dipeptidyl Peptidase-4 Inhibitors: Moderate Careful monitoring of blood glucose is recommended when hydroxychloroquine and antidiabetic agents, including the dipeptidyl peptidase-4 inhibitors, are coadministered. Diphenhydramine; Hydrocodone; Phenylephrine: Moderate Concomitant use of hydrocodone with hydroxychloroquine may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.
Disopyramide: Major Avoid coadministration of hydroxychloroquine and disopyramide. Disopyramide administration is also associated with QT prolongation and TdP.
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Dofetilide: Major Coadministration of dofetilide and hydroxychloroquine is not recommended as concurrent use may increase the risk of QT prolongation. Dolasetron: Major Avoid coadministration of hydroxychloroquine and dolasetron. Dolutegravir; Rilpivirine: Major Avoid coadministration of hydroxychloroquine and rilpivirine. Donepezil: Major Avoid coadministration of hydroxychloroquine and donepezil.
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Case reports indicate that QT prolongation and TdP can occur during donepezil therapy. Donepezil is considered a drug with a known risk of TdP. Donepezil; Memantine: Major Avoid coadministration of hydroxychloroquine and donepezil.