Drug: Azithromycin and Chloroquine Pfizer will provide Zithromax mg and Aralen mg containing mg chloroquine base. The study treatment is single dose.
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Pfizer will provide Zithromax mg and Aralen mg containing mg chloroquine base. Outcome Measures. Secondary Outcome Measures : Tmax of azithromycin and chloroquine for each treatment cohort. Eligibility Criteria.
Chloroquine Drug Interactions
The cleaning agent has the same active ingredient as the medicine chloroquine but is formulated differently. Chloroquine has been used to treat malaria since the s. Hydroxychloroquine came along a decade later and has fewer side effects. The latter is sold in generic form and under the brand name Plaquenil for use against several diseases. The drugs can cause heart rhythm problems, severely low blood pressure and muscle or nerve damage.
Plaquenil's label warns of possible damage to the retina, especially when used at higher doses, for longer times and with certain other medicines such as the breast cancer drug tamoxifen. Hydroxychloroquine is far safer, but its side effects are still significant," Meghan May, a microbiologist at the University of New England College of Osteopathic Medicine in Biddeford, Maine, wrote in an email. That's where the evidence comes in — and, so far, there is not much. Hydroxychloroquine curbed coronavirus' ability to enter cells in lab tests, researchers reported last week in the journal Nature Medicine.
That doesn't mean it would do the same in people or that they could tolerate the doses tested in the lab. A report from China claimed chloroquine helped more than patients at 10 hospitals, but they had various degrees of illness and were treated with various doses for different lengths of time.
They also might have recovered without the drug — there was no comparison group. The French study has attracted the most attention. Doctors gave hydroxychloroquine to 26 people with confirmed coronavirus infections, including some with no symptoms. Six also were given the antibiotic azithromycin. That's encouraging, but many things could have affected the outcome, such as how sick people were, when they were treated, what other treatments they received, as well as their age, gender and underlying health conditions.
Its biggest limitation: A drop in detected virus doesn't mean the drugs will improve survival or shorten illness. The supply already is pinched for patients who need the drugs for other reasons. A University of Utah service that tracks shortages says four of the seven companies that make generic hydroxychloroquine have reported them.